中药灌肠治疗小儿外感发热的meta分析

来源:用户上传      作者:黄亚玲 徐子尧 王芳

　　[摘要] 目的系y评价中药灌肠对小儿外感发热的疗效及安全性。方法计算机检索中国生物医学文献数据库（CBM）、中国知网（CNKI）、万方、维普、万方医学网、PubMed 数据库中所有涉及中药灌肠治疗小儿外感发热的随机对照研究（RCT），检索时限均为建库至2021年 8月。由2 名研究者独立筛选文献、提取资料、评价文献质量，采用 Rev Man 5.3软件对结果进行 meta 分析。结果共纳入18项 RCT，共2607例患儿。meta 分析结果显示：中药灌肠治疗小儿外感发热总有效率高于对照组[OR=3.54，95%CI（2.68，4.69）， P <0.00001]，退热起效时间[MD=-2.53，95%CI （-3.21，-1.85）， P <0.00001]、完全退热时间[MD=-6.09，95%CI（-7.05，-5.12），P <0.00001]均短于对照组，减少了体温反跳的发生[RR=0.35，95%CI（0.21，0.59），P <0.0001]，缩短了患儿住院时间[MD=-1.83，95%CI （-2.25，-1.41）， P <0.00001]，差异有统计学意义（P <0.05），但对不良反应的发生[RR=0.66，95%CI（0.42，1.01）， P=0.06]，差异无统计学意义（P >0.05）。结论中药灌肠治疗小儿外感发热疗效佳，安全性尚不明确，有待进一步评价。
　　[关键词] 中药灌肠;小儿;外感发热; Meta 分析
　　[中图分类号] R272 [文献标识码] A [文章编号] 2095-0616（2022）06-0032-06
　　Meta-analysis on TCM enema therapy for children with exopathic fever
　　HUANG YalingXU Ziyao1WANG Fang
　　1.School of Nursing， Chengdu University of Traditional Chinese Medicine， Sichuan， Chengdu 610075， China;2. Department of Nursing， Affiliated Hospital of Chengdu University of Traditional Chinese Medicine， Sichuan， Chengdu 610032， China
　　[Abstract] Objective To systematically evaluate the efficacy and safety of traditional Chinese medicine （TCM） enema therapy on children with exopathic fever. Methods All randomized controlled trials （RCTs） involving TCM enema therapy in the treatment of children with exopathic fever included in China Biology Medicine （CBM） disc， China National Knowledge Internet （CNKI）， Wanfang and VIP databases， Wanfang Med Online， and PubMed Database from database establishment to August 2021 were retrieved using computer. Literature screening， data extraction， and evaluation of literature quality were conducted by two investigators independently， and meta-analysis of the results was performed using Rev Man 5.3 software. Results A total of 18 RCTs with a total of 2607 children were included in this study. Meta-analysis results showed that the overall effective rate of TCM enema therapy for the treatment of children with exopathic fever was higher than that of the controls （OR=3.54， 95%CI [2.68， 4.69]， P <0.00001）， and the time to onset of fever abatement （MD=-2.53， 95%CI [-3.21，-1.85]， P <0.00001） and the time to complete fever abatement （MD=-6.09， 95%CI [-7.05， -5.12]， P <0.00001） were shorter than those in the controls. In addition， the occurrence of temperature rebound （RR =0.35， 95%CI [0.21， 0.59]， P <0.0001） was lower and the length of hospital stay （MD=-1.83， 95%CI[-2.25，-1.41]， P <0.00001） was shorter in children with exopathic fever treated with TCM enema therapy than those in the controls， all with statistically significant differences （P <0.05）. However， TCM enema therapy had no significant effects on the occurrence of adverse reactions （RR=0.66， 95%CI [0.42， 1.01]， P=0.06） in children with exopathic fever （P >0.05）. Conclusion TCM enema therapy is effective in treating children with exopathic fever， but the safety is unclear and further evaluation is required.

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