血糖波动对2型糖尿病合并肺癌患者化疗效果的影响及安全性分析

来源:用户上传      作者:高瑞新

　　[摘要]目的分析血糖波佣2型糖尿病合并肺癌患者化疗效果的影响及安全性。方法抽取2018年8月至2020年12月东营市中医院就诊的50例2型糖尿病合并肺癌患者作为研究对象，根据血糖波动幅度将患者划分为两组，参数正常的25例患者分为对照组，另外血糖波动幅度较大（平均血糖波动幅度≥3.9 mmol/L）的25例患者分为观察组。比较两组2型糖尿病合并肺癌患者化疗后的血糖、血清炎症因子、肿瘤标志物水平与不良反应发生情况。结果观察组空腹血糖、进食后 h 血糖以及最大血糖波动幅度均高于对照组，差异有统计学意义（P <0.05）;观察组患者的糖类抗原、细胞角蛋白、癌胚抗原、肿瘤坏死因子以及高敏 C 反应蛋白高于对照组，差异有统计学意义（P<0.05）;观察组不良反应总发生率为32.00%，高于对照组的12.00%，差异有统计学意义（P <0.05）。结论血糖波动幅度较大会对2型糖尿病合并肺癌患者的治疗效果造成较大影响，使炎症细胞因子和肿瘤标志物水平处于难以控制的状态，不良反应发生率较高，安全性较低。 [关键词]血糖波动;肺癌;不良反应;化疗效果
　　[中图分类号] R587.1;R734. [文献标识码] A [文章编号]2095-0616（2022）14-0150-03
　　Analysis on the impact of blood glucose fluctuation on chemotherapy efficacy and safety in patients with type diabetes mellitus complicated with lung cancer
　　GAO Ruixin
　　Department of Endocrinology， Hospital of Traditional Chinese Medicine of Dongying City， Shandong， Dongying 257055， China
　　[Abstract] Objective To analyze the impact of blood glucose fluctuation on chemotherapy efficacy and safety in patients with type diabetes mellitus （T2DM） complicated with lung cancer. Methods A total of 50 patients with T2DM complicated with lung cancer admitted to the Hospital of Traditional Chinese Medicine of Dongying City in Shandong Province from August 2018 to December 2020 were selected as research subjects. And they were divided into the control group （n=25） and the observation group （n=25） according to the fluctuation range of blood glucose. The control group was in normal parameters， while the observation group was in large fluctuation range of blood glucose （mean fluctuation range of blood glucose ≥3.9 mmol/L）. After chemotherapy， the levels of blood glucose， serum inflammatory factors， tumor markers and the incidence of adverse reactions （ARs） were compared between the two groups of patients with T2DM complicated with lung cancer. Results It was found that the levels of fasting blood glucose and blood glucose at h after eating， and maximum fluctuation range of blood glucose in the observation group were higher than those in the control group， with statistically significant differences （P <0.05）. The levels of carbohydrate antigen， cytokeratin， carcinoembryonic antigen， tumor necrosis factor and high-sensitivity C-reactive protein of patients in the observation group were higher than those in the control group， with statistically significant differences （P <0.05）. The incidence of ARs in the observation group was 32%， higher than 12% in the control group， with statistically significant difference （P <0.05）. Conclusion According to the results of this research， it is found that the large fluctuation range of blood glucose has a great impact on the therapeutic efficacy of patients with T2DM complicated with lung cancer. It makes the levels of inflammatory cytokines and tumor markers in an uncontrollable state， and incurs high incidence of ARs and low safety in patients.

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