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  • 氯吡格雷联合阿司匹林在脑梗死疾病治疗中的应用效果及其对动脉硬化的影响

氯吡格雷联合阿司匹林在脑梗死疾病治疗中的应用效果及其对动脉硬化的影响

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   【摘要】 目的:探析阿司匹林联合氯吡格雷在脑梗死疾病治疗中应用价值及其对动脉硬化的影响。方法:本次75例脑梗死患者均为笔者所在医院2018年2-11月接收,根据入院先后时间分为两组,参照组(n=37)进行常规治疗,试验组(n=38)在常规治疗的同时,联合氯吡格雷与阿司匹林,统计各组血小板活性及动脉硬化指标。结果:试验组红细胞沉降率、高切全血黏度、血小板黏附率、血小板抑制率、斑块数量、脂联素、IMT及磷脂酸均优于参照组,差异均有统计学意义(P<0.05)。结论:阿司匹林联合氯吡格雷在脑梗死疾病治疗中应用效果明显,不仅可以减轻患者临床病症,避免血小板聚集,同时有助于动脉硬化指标改善,值得推广并采纳。
   【关键词】 阿司匹林; 脑梗死; 氯吡格雷; 血小板活性; 动脉硬化
   doi:10.14033/j.cnki.cfmr.2019.20.054 文献标识码 B 文章编号 1674-6805(2019)20-0-03
   Effect of Clopidogrel Combined with Aspirin in Treatment of Cerebral Infarction and the Effect of Atherosclerosis/HUANG Yanzhi,WANG Qin.//Chinese and Foreign Medical Research,2019,17(20):-123
   【Abstract】 Objective:To explore the application value of Aspirin combined with Clopidogrel in treatment of cerebral infarction and its effect on atherosclerosis.Method:A total of 75 patients with cerebral infarction were received in our hospital from February to November 2018.According to the time of admission,they were divided into two groups.The control group(n=37) was treated with routine therapy,while the experimental group(n=38) was treated with Clopidogrel and Aspirin.The platelet activity and atherosclerosis index of each group were counted.Result:The erythrocyte sedimentation rate,high shear whole blood viscosity,platelet adhesion rate,platelet inhibition rate,plaque number,adiponectin,IMT and phospholipid acid in the experimental group were significantly higher than those in the control group(P<0.05).Conclusion:Aspirin combined with Clopidogrel is effective in the treatment of cerebral infarction.It can not only reduce the clinical symptoms and avoid platelet aggregation,but also help to improve the index of arteriosclerosis,which is worth popularizing and adopting.
   【Key words】 Aspirin; Cerebral infarction; Clopidogrel; Platelet activity; Atherosclerosis
   First-author’s address:Xuan’en County People’s Hospital,Xuan’en 445500,China
   腦梗死是临床神经内科较为常见的一种疾病,该病又被称为缺血性卒中,中医将其视为中风或者卒中。此类疾病指的是在诸多因素共同作用下导致局部脑组织血液供应受限,脑组织缺氧、缺血性病变坏死的一种疾病[1]。临床表现以神经功能缺失为主[2]。此类疾病诱发机制包括心脏病、遗传、糖尿病、高血压及吸烟等,发病人群多为中老年人。疾病发病突然,有些患者病情相对严重,提高了脑水肿、瘫痪、失语等发生率,有些甚至死亡,对预后造成了影响[3]。及早开展有效治疗,可对疾病发展进行控制,使死亡率、致残率降低[4]。现阶段,临床主要采取静脉溶栓、抗血小板、抗凝及抗自由基等方法进行治疗。基于此,本次试验针对2018年2-11月笔者所在医院接收的75例脑梗死患者采取氯吡格雷联合阿司匹林治疗效果进行简单分析,以下为具体报道。
  1 资料与方法
  1.1 一般资料
   选取笔者所在医院2018年2-11月接收的75例脑梗死患者。纳入标准:确诊为脑梗死;具备完整临床资料。排除标准:(1)合并肝脏、肾脏及心脏器官功能不全;(2)存在精神异常及心理障碍;(3)言语沟通障碍及神志模糊;(4)因个人因素中途退出或者拒绝参与本次试验。随机分为参照组及试验组。参照组
  37例,男19例,女18例;年龄42~75岁,平均(55.46±3.19)岁;
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