康凝胶联合干扰素栓治疗持续高危型HPV感染的临床疗效

来源:用户上传      作者:倪泞 陈丽珍 陈龙山

　　[摘要] 目的 ^察康凝胶联合干扰素栓治疗持续高危型HPV感染的临床疗效。方法 选取2019年7月至2020年5月江西省景德镇市第一人民医院60例持续高危型HPV感染患者作为研究对象，按照随机数字表法分为观察组（康凝胶联合干扰素栓治疗）与对照组（干扰素治疗），每组30例。比较两组患者的治疗前后炎症因子水平及免疫功能指标、治疗效果及HR-HPV转阴情况。结果 两组患者的CRP、IL-6及PCT炎症因子指标治疗后均低于治疗前，观察组治疗后的各项炎症因子水平较对照组低（P<0.05），有统计学意义;治疗前两组的各项免疫功能无差异，治疗后观察组改善幅度更大，与对照组差异有统计学意义（P<0.05）;两组患者的总有效率比较观察组高于对照组（93.33%vs.70.0%），有统计学意义（P<0.05）;观察组治疗后3个月的HR-HPV转阴率达到90.00%（27/30）高于对照组的63.33%（19/30），差异有统计学意义（P<0.05）。结论 康凝胶联合干扰素栓治疗持续高危型HPV感染，在改善炎症因子水平、提升免疫功能方面有着突出效果，有利于HPV转阴，疗效确切，可予以推广。
　　[关键词] 康凝胶;干扰素栓;高危型HPV感染;炎症因子;免疫功能;HPV转阴
　　[中图分类号] R711 [文献标识码] B [文章编号] 1673-9701（2022）13-0047-04
　　[Abstract] Objective To observe the clinical efficacy of Kang gel combined with interferon suppository in the treatment of persistent high-risk human papillomavirus （HR-HPV） infection. Methods A total of 60 patients with persistent HR-HPV infection in Jingdezhen NO.1 People′s Hospital in Jiangxi Province from July 2019 to May 2020 were selected as study subjects and divided into the observation group （treated with Kang gel combined with interferon suppository） and the control group （treated with interferon）according to the random number table method， with 30 cases in each group. The level of inflammatory factors and immune function indexes before and after treatment， as well as the efficacy and negative conversion of HR-HPV were compared between the two groups. Results The levels of inflammatory factors such as C-reactive protein （CRP）， interleukin-6 （IL-6） and procalcitonin （PCT） in both groups after treatment were lower than those before treatment， and those in the observation group were lower than those in the control group after treatment， with statistically significant differences （P<0.05）.There was no difference between the two groups in immune function before treatment， and the improvement in immune function of the observation group was greater than that of the control group after treatment， withstatistically significant differences （P<0.05）. The total effective rate of patients in the observation group was higher than that in the control group （93.33% vs. 70.0%）， withstatistically significant differences （P<0.05）.The rate ofnegative conversion of HR-HPV in the observation group was 90.00% （27/30） higher than 63.33% （19/30） in the control group3 months after treatment， withstatistically significant differences （P<0.05）. Conclusion In the treatment of persistent HR-HPV infection， Kang gel combined with interferon suppository has outstanding and definite efficacy in improving the level of inflammatory factors and enhancing immune function， which is conducive to the negativeconversion of HPV， and can be promoted.

nlc202206161034

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