您好, 访客   登录/注册
  •  > 中国论文网 > 
  • 医学论文  > 
  • 鼻内镜手术结合鼻腔冲洗液治疗慢性鼻窦炎的效果及其对炎症因子的影响观察

鼻内镜手术结合鼻腔冲洗液治疗慢性鼻窦炎的效果及其对炎症因子的影响观察

来源:用户上传      作者:

  【摘要】 目的 探讨鼻内镜手术结合鼻腔冲洗液治疗慢性鼻窦炎的效果及其对炎症因子的影响。方法 78例慢性鼻窦炎患者, 随机分为观察组和对照组, 每组39例。两组患者均进行鼻内镜手术治疗, 观察组给予布地奈德鼻腔冲洗, 对照组给予生理盐水鼻腔冲洗。比较两组患者的治疗效果、治疗前后相关炎性因子水平变化情况。结果 观察组患者治疗总有效率为94.87%(37/39), 高于对照组的79.49%
  (31/39), 差异具有统计学意义(P<0.05)。治疗前, 两组患者白细胞介素(IL)-2、IL-4、IL-6、干扰素(IFN)-γ水平比较差异无统计学意义(P>0.05);治疗后, 观察组患者IL-2、IL-4、IL-6、IFN-γ水平均低于对照组, 差异均有统计学意义(P<0.05)。结论 慢性鼻窦炎患者应用鼻内镜手术结合鼻腔冲洗液治疗能有效缓解炎症反应, 其中以布地奈德冲洗效果更加显著。
  【关键词】 慢性鼻窦炎;鼻内镜手术;鼻腔冲洗液
  DOI:10.14163/j.cnki.11-5547/r.2019.18.010
  Observation on effect of endoscopic sinus surgery combined with nasal irrigation on the treatment of chronic sinusitis and its influence on inflammatory factors   WEI Lin, LI Hua-ying, XUAN Zi-cai. Department of Otorhinolaryngology and Head and Neck Surgery, Guangdong Yangchun People’s Hospital, Yangchun 529600, China
  【Abstract】 Objective   To discuss the effect of endoscopic sinus surgery combined with nasal irrigation on the treatment of chronic sinusitis and its influence on inflammatory factors. Methods   A total of 78 chronic sinusitis patients were randomly divided into observation group and control group, with 39 cases in each group. Both groups was treated with endoscopic sinus surgery. The observation group received budesonide nasal irrigation, and the control group received saline nasal irrigation. Comparison were made on treatment effect and changes of related inflammatory factors before and after treatment between the two groups. Results   The observation group had higher total treatment effective rate as 94.87%(37/39) than 79.49%(31/39) in the control group, and the difference was statistically significant (P<0.05). Before treatment, both groups had no statistically significant difference in interleukin (IL)-2, IL-4, IL-6 and inteferon (IFN)-γ (P>0.05). After treatment, the observation group had lower IL-2, IL-4, IL-6 and IFN-γ than the control group, and their difference was statistically significant (P<0.05). Conclusion   Endoscopic surgery combined with nasal irrigation can effectively alleviate the inflammatory response in patients with chronic sinusitis, and the effect of budesonide irrigation is more significant.
  【Key words】 Chronic sinusitis; Endoscopic sinus surgery; Nasal irrigation
  慢性鼻竇炎是鼻腔、鼻窦黏膜发生慢性炎症性病变, 多是因为急性鼻窦炎未得到彻底的治愈反复发作迁延而来, 同时鼻窦腔内分泌物形态、窦口通畅程度、鼻纤毛的传输功能等均与慢性鼻窦炎的产生有关系[1]。鼻内镜手术是慢性鼻窦炎的首选治疗方法, 本文旨在探讨鼻内镜手术结合不同鼻腔冲洗液治疗慢性鼻窦炎的效果, 现报告如下。
  1 资料与方法
  1. 1 一般资料 选择2017年1月~2018年8月本院收治的78例慢性鼻窦炎患者作为研究对象, 随机分为观察组和对照组, 每组39例。观察组患者中男20例, 女19例;平均年龄(39.62±9.52)岁;平均病程(3.02±1.03)年;发病位置:单侧27例, 双侧12例。对照组患者中男18例, 女21例;平均年龄(38.52±8.41)岁;平均病程(3.11±1.12)年;发病位置:单侧28例, 双侧11例。两组患者性别、年龄、病程等一般资料比较差异无统计学意义(P>0.05), 具有可比性。纳入标准:①均有流涕、鼻塞、嗅觉减退、头痛等症状;②鼻腔内黏膜红肿;③鼻窦CT异常表现。排除标准:①其他鼻腔疾病;②鼻腔结构畸形;③鼻咽、鼻腔肿瘤;④心脏疾病;⑤不能按时复诊者。
转载注明来源:https://www.xzbu.com/6/view-14914075.htm

服务推荐